| 000 | 02343nam a2200301Ia 4500 | ||
|---|---|---|---|
| 003 | MX-MdCICY | ||
| 005 | 20260521091803.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-767 | ||
| 245 | 1 | 0 | _aThe Combinatory Effects of Essential Oil from Lippia macrophylla on Multidrug Resistant Acinetobacter baumannii Clinical Isolates |
| 490 | 0 | _aChemistry & Biodiversity, p.e202400537, 2024 | |
| 500 | _aArtículo | ||
| 520 | 3 | _aTo assess the antibacterial effectiveness of Lippia macrophylla essential oil (LMEO) against multidrug-resistant Acinetobacter baumannii isolates, both as a standalone treatment and in combination with conventional antibiotics. LMEO demonstrated a significant inhibitory effect on the growth of A. baumannii, with a minimum inhibitory concentration (MIC) below 500 μg/ mL. Notably, LMEO was capable of reversing the antibiotic resistance of clinical isolates or reducing their MIC values when used in combination with antibiotics, showing synergistic (FICI 0.5) or additive effects. The combination of LMEO and imipenem was particularly effective, displaying synergistic interactions for most isolates. Ultrastructural analyses supported these findings, revealing that the combination of LMEO+ ceftazidime compromised the membrane integrity of the Acb35 isolate, leading to cytoplasmic leakage and increased formation of Outer Membrane Vesicles (OMVs). Taken together our results point for the use of LMEO alone or in combination as an antibacterial agent against A. baumannii. These findings offer promising avenues for utilizing LMEO as a novel antibacterial strategy against drug-resistant infections in healthcare settings, underscoring the potential of essential oils in enhancing antibiotic efficacy. | |
| 650 | 1 | 4 | _aACINETOBACTER BAUMANNII |
| 650 | 1 | 4 | _aCOMBINATION THERAPY |
| 650 | 1 | 4 | _aESSENTIAL OILS |
| 650 | 1 | 4 | _aULTRASTRUCTURE |
| 700 | 1 | 2 | _ada Silva Cirino, I. |
| 700 | 1 | 2 | _aFerrera de Santana, C. |
| 700 | 1 | 2 | _aRocha, I. |
| 700 | 1 | 2 | _aOliveira de Souza, L. |
| 700 | 1 | 2 | _aVanusa Silva, M. |
| 700 | 1 | 2 | _aBresan Queriz Figueiredo, R. |
| 700 | 1 | 2 | _aLeal-Balbino, T. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1rH-u_CwkChs1njt0T6oTQwMGT8qWF7jw/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 |
_2Loc _cREF1 |
||
| 008 | 250602s9999 xx |||||s2 |||| ||und|d | ||
| 999 |
_c31433 _d31433 |
||