02093nam a2200313Ia 4500 MX-MdCICY 20260521092149.0 CICY B-21967 Pioneering NMR-based dereplication for identifying novel quinolone additives in personal care products: A new frontier in public health protection. Talanta, 285, 127304, 2025. Artículo Personal care products (PCPs) are often adulterated with antimicrobial agents, such as quinolones, which pose risks to consumer safety and challenge regulatory oversight. Current detection methods rely on standard reference substances and are limited in identifying novel quinolone isomers and structural derivatives. In this study, we present the first use of MixONat, an advanced dereplication tool, combined with 13C NMR spectroscopy to detect illegal quinolone additives in PCPs. Key advancements include the establishment of an in-house quinolone database, innovative sample pretreatment methods, and the integration of these elements to improve the detection of new illegal additives in PCPs. Standard addition experiments in both blank matrices and commercial cosmetics successfully identified new quinolones not included in the database, with effective differentiation of stereoisomers such as ofloxacin and levofloxacin. The proposed approach significantly improves detection efficiency and accuracy, bolstering PCP safety regulations and contributing to public health protection. PERSONAL CARE PRODUCTS NMR DEREPLICATION QUINOLONE ADDITIVES ILLEGAL ADDITIVES MIXONAT PUBLIC HEALTH PROTECTION Du, X. Lin, X. Yuan, R. Yang, H. Lu, Y. Wu, X. https://drive.google.com/file/d/1NW4Lq4OfsmOQFLl-Yze3W4zucxAZ9g2-/view?usp=drive_link Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 251009s9999 xx 000 0 und d 37983 37983 0 0 Loc 0 0 F1 CICY CICY RE 2025-10-09 0 B-21967 2025-10-09 16:07:11 2025-10-09 REF1