02273nam a2200325Ia 4500003001000000005001700010040000900027090001200036245006100048490003900109500001500148520127300163650002001436650001601456650002101472650000801493650001101501700001101512700001101523700001801534700001601552700001301568700001701581700001601598856015801614942001401772008004101786999001701827952010301844MX-MdCICY20260521092146.0  cCICY  aB-2185710aElevated snoRNA biogenesis is essential in breast cancer0 aOncogene, 33(1), p.1348-1358, 2014  aArtículo3 aHyperactive ribosomal biogenesis is widely observed in cancer, which has been partly attributed to the increased rDNA transcription by Pol I in cancer. However, whether small nucleolar RNAs (snoRNAs), a class of non-coding RNAs crucial in ribosomal RNA (rRNA) maturation and functionality, are involved in cancer remains elusive. We report that snoRNAs and fibrillarin (FBL, an enzymatic small nucleolar ribonucleoprotein, snoRNP) are frequently overexpressed in both murine and human breast cancer as well as in prostate cancers, and significantly, that this overexpression is essential for tumorigenicity in vitro and in vivo. We demonstrate that when the elevated snoRNA pathway is suppressed, the tumor suppressor p53 can act as a sentinel of snoRNP perturbation, the activation of which mediates the growth inhibitory effect. On the other hand, high level of FBL interferes with the activation of p53 by stress. We further show that p53 activation by FBL knockdown is not only regulated by the ribosomal protein[1]MDM2-mediated protein stabilization pathway, but also by enhanced PTB-dependent, cap-independent translation. Together, our data uncover an essential role of deregulated snoRNA biogenesis in tumors and a new mechanism of nucleolar modulation of p53.14aBREAST CÁNCER14aFIBRILLARIN14aNUCLEOLAR STRESS14aP5314aSNORNA12aSu, H.12aXu, T.12aGanapathy, S.12aShadfan, M.12aLong, M.12aHuang, T. H.12aYuan, Z. M.40uhttps://drive.google.com/file/d/13fa2NBfRE9kE1HhmVshhkMbRMznjpyf2/view?usp=drive_linkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx  2LoccREF1251009s9999    xx            000 0 und d  c37877d37877  00102Loc40708F1aCICYbCICYcREd2025-10-09l0oB-21857r2025-10-09 16:07:07w2025-10-09yREF1