02156nam a2200313Ia 4500 MX-MdCICY 20260521092146.0 CICY B-21857 Elevated snoRNA biogenesis is essential in breast cancer Oncogene, 33(1), p.1348-1358, 2014 Artículo Hyperactive ribosomal biogenesis is widely observed in cancer, which has been partly attributed to the increased rDNA transcription by Pol I in cancer. However, whether small nucleolar RNAs (snoRNAs), a class of non-coding RNAs crucial in ribosomal RNA (rRNA) maturation and functionality, are involved in cancer remains elusive. We report that snoRNAs and fibrillarin (FBL, an enzymatic small nucleolar ribonucleoprotein, snoRNP) are frequently overexpressed in both murine and human breast cancer as well as in prostate cancers, and significantly, that this overexpression is essential for tumorigenicity in vitro and in vivo. We demonstrate that when the elevated snoRNA pathway is suppressed, the tumor suppressor p53 can act as a sentinel of snoRNP perturbation, the activation of which mediates the growth inhibitory effect. On the other hand, high level of FBL interferes with the activation of p53 by stress. We further show that p53 activation by FBL knockdown is not only regulated by the ribosomal protein[1]MDM2-mediated protein stabilization pathway, but also by enhanced PTB-dependent, cap-independent translation. Together, our data uncover an essential role of deregulated snoRNA biogenesis in tumors and a new mechanism of nucleolar modulation of p53. BREAST CÁNCER FIBRILLARIN NUCLEOLAR STRESS P53 SNORNA Su, H. Xu, T. Ganapathy, S. Shadfan, M. Long, M. Huang, T. H. Yuan, Z. M. https://drive.google.com/file/d/13fa2NBfRE9kE1HhmVshhkMbRMznjpyf2/view?usp=drive_link Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 251009s9999 xx 000 0 und d 37877 37877 0 0 Loc 0 0 F1 CICY CICY RE 2025-10-09 0 B-21857 2025-10-09 16:07:07 2025-10-09 REF1