03175nam a22004815i 4500 978-1-4020-4407-6 DE-He213 20260521092108.0 cr nn 008mamaa 100301s2007 ne | s |||| 0|eng d 9781402044076 99781402044076 10.1007/1-4020-4407-0 doi 615.19 23 Jhoti, Harren. author. Structure-Based Drug Discovery [electronic resource] / by Harren Jhoti, Andrew R. Leach. Dordrecht : Springer Netherlands, 2007. XII, 249 p. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis -- Protein Production for Structural Genomics - Strategies for the Next Phase -- to Fragment Screening -- Fragment-Based NMR Screening in Lead Discovery -- Fragment-Based Screening by X-ray Crystallography -- Scaffold-Based Drug Discovery -- Biophysical Methods -- Illustration of Current Challenges in Molecular Docking -- Scoring Functions. Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. Structure-based drug discovery describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being used worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications. This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology. CHEMISTRY. CHEMISTRY, PHYSICAL ORGANIC. BIOCHEMISTRY. PHARMACY. CHEMISTRY. MEDICINAL CHEMISTRY. BIOCHEMISTRY, GENERAL. PHARMACY. PHYSICAL CHEMISTRY. COMPUTER APPLICATIONS IN CHEMISTRY. Leach, Andrew R. author. SpringerLink (Online service) Springer eBooks Printed edition: 9781402044069 http://dx.doi.org/10.1007/1-4020-4407-0 Ver el texto completo en las instalaciones del CICY ZDB-2-CMS ddc ER 36786 36786 0 0 ddc 0 0 LE CICY CICY EL 2025-10-06 0 615.19 2025-10-06 08:45:09 2025-10-06 ER