03978nam a22004215i 4500 978-1-4020-3186-1 DE-He213 20260521092051.0 cr nn 008mamaa 100301s2005 ne | s |||| 0|eng d 9781402031861 99781402031861 10.1007/978-1-4020-3186-1 doi 614.5999 23 Schulz, Wolfgang Arthur. author. Molecular Biology of Human Cancers [electronic resource] : An Advanced Student's Textbook / by Wolfgang Arthur Schulz. Dordrecht : Springer Netherlands, 2005. XIX, 508 p. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Molecules, Mechanisms, And Cells -- An Introduction to Human Cancers -- An Introduction to Human Cancers -- DNA Damage and DNA Repair -- Oncogenes -- Tumor Suppressor Genes -- Cancer Pathways -- Apoptosis and Replicative Senescence in Cancer -- Cancer Epigenetics -- Invasion and metastasis -- Human Cancers -- Leukemias and Lymphomas -- Wilms Tumor (nephroblastoma) -- Cancers of the skin -- Colon Cancer -- Bladder Cancer -- Renal Cell Carcinoma -- Liver Cancer -- Stomach Cancer -- Breast Cancer -- Prostate Cancer -- Prevention, Diagnosis, And Therapy -- Cancer Prevention -- Cancer Diagnosis -- Cancer Therapy. Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other. MEDICINE. ONCOLOGY. BIOMEDICINE. CANCER RESEARCH. MOLECULAR MEDICINE. ONCOLOGY. SpringerLink (Online service) Springer eBooks Printed edition: 9781402031854 http://dx.doi.org/10.1007/978-1-4020-3186-1 Ver el texto completo en las instalaciones del CICY ZDB-2-SBL ddc ER 36296 36296 0 0 ddc 0 0 LE CICY CICY EL 2025-10-06 0 614.5999 2025-10-06 08:44:52 2025-10-06 ER