03915nam a22004335i 4500001001800000003000900018005001700027007001500044008004100059020001800100020001900118024003500137040000900172082001600181100003400197245010600231264004600337300002100383336002600404337002600430338003900456347002400495490005700519505106900576520144401645650001503089650001803104650001403122650002003136650001503156650002003171650002603191650001403217710003403231773002003265776003603285830005703321856010303378978-0-387-76554-9DE-He21320260521091956.0cr nn 008mamaa100301s2008    xxu|    s    |||| 0|eng d  a9780387765549  a997803877655497 a10.1007/978-0-387-76554-92doi  cCICY04a620.1152231 aTorchilin, Vladimir.eeditor.10aMultifunctional Pharmaceutical Nanocarriersh[recurso electrónico] /cedited by Vladimir Torchilin. 1aNew York, NY :bSpringer New York,c2008.  bonline resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  arecurso en líneabcr2rdacarrier  atext filebPDF2rda1 aFundamental Biomedical Technologies,x1559-7083 ;v40 aMultifunctional Pharmaceutical Nanocarriers: Development of the Concept -- Multifunctional Polymeric Nanosystems for Tumor-Targeted Delivery -- Nanogels as Pharmaceutical Carriers -- Multifunctional Water-Soluble Polymers for Drug Delivery -- "Smart" pH-Responsive Carriers for Intracellular Delivery of Biomolecular Drugs -- Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery -- Functionalized Dendrimers as Nanoscale Drug Carriers -- Biodegradable Multitargeting Nanoconjugates for Drug Delivery -- Pharmaceutical Micelles: Combining Longevity, Stability, and Stimuli Sensitivity -- Multifunctional Nanotherapeutics for Cancer -- Charge Modification of Pharmaceutical Nanocarriers: Biological Implications -- Funtionalization of Pharmaceutical Nanocarriers for Mitochondria-Targeted Drug and DNA Delivery -- Multifunctional Magnetic Nanosystems for Tumor Imaging, Targeted Delivery, and Thermal Medicine -- Nanosystems for Multimodality In vivo Imaging -- Long-Circulating Liposomes with Attached Diagnostic Moieties: Application for Gamma and MR Imaging.  aVarious pharmaceutical nanocarriers, such as nanospheres,nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established itself over the past decade both in pharmaceutical research and clinical setting. Looking into the future of the field of drug delivery, we have to think about the development of the next generation of pharmaceutical nanocarriers combining the whole variety of properties and allowing for the simultaneous performance of multiple functions. Surface modification of pharmaceutical carriers is often used to control their properties in a desirable fashion and make them to simultaneously perform several different functions. This book is all about these "futuristic" multifunctional medicines. Key features: -all chapters written by international leaders in the field -offers the most recent innovations and discoveries related to nanopharmaceuticals -detailed illustrations -latest volume in the Fundamental Biomedical Technologies series About the Editor: Vladimir P. Torchilin, Ph.D., D.Sc. is a Distinguished Professor and Chair of the Department of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Mass. 0aCHEMISTRY. 0aMICROBIOLOGY. 0aPHARMACY. 0aNANOTECHNOLOGY.14aCHEMISTRY.24aNANOTECHNOLOGY.24aMEDICAL MICROBIOLOGY.24aPHARMACY.2 aSpringerLink (Online service)0 tSpringer eBooks08iPrinted edition:z9780387765518 0aFundamental Biomedical Technologies,x1559-7083 ;v440uhttp://dx.doi.org/10.1007/978-0-387-76554-9zVer el texto completo en las instalaciones del CICY