02343nam a2200301Ia 4500 MX-MdCICY 20260521091803.0 CICY B-767 The Combinatory Effects of Essential Oil from Lippia macrophylla on Multidrug Resistant Acinetobacter baumannii Clinical Isolates Chemistry & Biodiversity, p.e202400537, 2024 Artículo To assess the antibacterial effectiveness of Lippia macrophylla essential oil (LMEO) against multidrug-resistant Acinetobacter baumannii isolates, both as a standalone treatment and in combination with conventional antibiotics. LMEO demonstrated a significant inhibitory effect on the growth of A. baumannii, with a minimum inhibitory concentration (MIC) below 500 μg/ mL. Notably, LMEO was capable of reversing the antibiotic resistance of clinical isolates or reducing their MIC values when used in combination with antibiotics, showing synergistic (FICI 0.5) or additive effects. The combination of LMEO and imipenem was particularly effective, displaying synergistic interactions for most isolates. Ultrastructural analyses supported these findings, revealing that the combination of LMEO+ ceftazidime compromised the membrane integrity of the Acb35 isolate, leading to cytoplasmic leakage and increased formation of Outer Membrane Vesicles (OMVs). Taken together our results point for the use of LMEO alone or in combination as an antibacterial agent against A. baumannii. These findings offer promising avenues for utilizing LMEO as a novel antibacterial strategy against drug-resistant infections in healthcare settings, underscoring the potential of essential oils in enhancing antibiotic efficacy. ACINETOBACTER BAUMANNII COMBINATION THERAPY ESSENTIAL OILS ULTRASTRUCTURE da Silva Cirino, I. Ferrera de Santana, C. Rocha, I. Oliveira de Souza, L. Vanusa Silva, M. Bresan Queriz Figueiredo, R. Leal-Balbino, T. https://drive.google.com/file/d/1rH-u_CwkChs1njt0T6oTQwMGT8qWF7jw/view?usp=drive_link Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 31433 31433 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-26 0 B-767 2025-06-26 08:09:24 2025-06-26 REF1