Ohizumi, H. Masuda, Y. Nakajo, S. Sakai, I. Ohsawa, S. Nakaya, K. text xx 9999 monographic und

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We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM. APOPTOSIS GERANYLGERANIOL ISOPRENOID TUMOR CELL https://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk https://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk 250602 20260521091744.0