01418nam a2200277Ia 4500 MX-MdCICY 20260521091744.0 CICY B-20824 Geranylgeraniol is a potent inducer of apoptosis in tumor cells The Journal of BioChemistry, 117(1), p.11-13, 1995 We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM. APOPTOSIS GERANYLGERANIOL ISOPRENOID TUMOR CELL Ohizumi, H. Masuda, Y. Nakajo, S. Sakai, I. Ohsawa, S. Nakaya, K. https://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 30843 30843 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-20824 2025-06-25 16:24:56 2025-06-25 REF1