01339nam a2200241Ia 4500003001000000005001700010040000900027245006800036490005500104520058700159650001400746650002000760650001500780650001500795700001600810700001500826700001500841700001400856700001500870700001500885856015600900008004101056MX-MdCICY20260521091744.0  cCICY10aGeranylgeraniol is a potent inducer of apoptosis in tumor cells0 vThe Journal of BioChemistry, 117(1), p.11-13, 19953 aWe screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.14aAPOPTOSIS14aGERANYLGERANIOL14aISOPRENOID14aTUMOR CELL12aOhizumi, H.12aMasuda, Y.12aNakajo, S.12aSakai, I.12aOhsawa, S.12aNakaya, K.40uhttps://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d