01950nam a2200313Ia 4500003001000000005001700010040000900027090001200036245011800048490003600166520088100202650002201083650003001105650002001135650003001155650001401185700001101199700001201210700001401222700001601236700001701252700002001269700001601289856015601305942001401461008004101475999001701516952010301533MX-MdCICY20260521091733.0  cCICY  aB-2045310aInduction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach0 vTetrahedron, 79, p.131876, 20213 aTen new ambuic acid derivatives, pestallic acids H-Q including one new iodinated natural product along with two known compounds, ambuic acid and ambuic acid 18-acetate, were obtained through fermentation of the endophytic fungus Pestalotiopsis lespedezae on solid rice medium with 3.5 percent NaI. Pestallic acids H-Q were undetectable in cultures of the fungus grown on solid rice medium lacking NaI or in those where NaI had been replaced by NaCl or NaBr. The structures of the new metabolites were established on basis of 1D/2D NMR and HRESIMS data. Their absolute configurations were determined by Mosher's method and TDDFT-ECD calculations. The compounds failed to show antibacterial activity against S. aureus (ATCC29213), drug-resistant Acinetobacter baumannii (BAA1605)or Mycobacterium tuberculosis, as well as cytotoxicity against the mouse lymphoma cell line L5178Y.14aENDOPHYTIC FUNGUS14aPESTALOTIOPSIS LESPEDEZAE14aPESTALLIC ACIDS14aIODINATED NATURAL PRODUCT14aTDDFT-ECD12aYu, X.12aGao, Y.12aFrank, M.12aMándi, A.12aKurtán, T.12aMüller, W. E.12aProksch, P.40uhttps://drive.google.com/file/d/1kIItIE2qmE5NNzn6gr-kzYXkm-sH8_U7/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx  2LoccREF1250602s9999    xx |||||s2   |||| ||und|d  c30484d30484  00102Loc40708F1aCICYbCICYcREd2025-06-25l0oB-20453r2025-06-25 16:24:49w2025-06-25yREF1