02066nam a2200289Ia 4500 MX-MdCICY 20260521091722.0 CICY B-20094 Anti-influenza activity of betulinic acid from Zizyphus jujuba on influenza A/PR/8 virus Biomolecules & Therapeutics, 23(4), p.345-349, 2015 Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinociceptive, and anticancer activities. In the study, we investigated the antiviral activity on influenza A/PR/8 virus infected A549 human lung adenocarcinoma epithelial cell line and C57BL/6 mice. Betulinic acid showed the anti-influenza viral activity at a concentration of 50 ?M without a significant cytotoxicity in influenza A/PR/8 virus infected A549 cells. Also, betulinic acid significantly attenuated pulmonary pathology including increased necrosis, numbers of inflammatory cells and pulmonary edema induced by influenza A/PR/8 virus infection compared with vehicle- or oseltamivir-treated mice in vivo model. The down-regulation of IFN-? level, which is critical for innate and adaptive immunity in viral infection, after treating of betulinic acid in mouse lung. Based on the obtained results, it is suggested that betulinic acid can be the potential therapeutic agent for virus infection via anti-inflammatory activity. BETULINIC ACID ZIZYPHUS JUJUBA INFLUENZA A/PR/8 A549 INFLAMMATION Hong, E. H. Song, J. H. Kang, K. B. Sung, S. H. Ko, H. J. Yang, H. https://drive.google.com/file/d/1GRpsusCFfyhqQz--jIVFumvQhr0rVQkB/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 30137 30137 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-20094 2025-06-25 16:24:42 2025-06-25 REF1