01468nam a2200229Ia 4500003001000000005001700010040000900027245011000036490004000146520066900186650003100855650004600886650001500932650002500947650001400972700001100986700001600997700001101013700001701024856015601041008004101197MX-MdCICY20260521091658.0  cCICY10aXanthones from the stems of Calophyllum membranaceum Gardn. et Champ.and their anti-inflammatory activity0 vPhytoChemistry, 200, p.113246, 20223 aEighteen undescribed xanthones, including six pairs of xanthone enantiomers, three xanthones, and three xanthone glycosides, together with one pair of known xanthone enantiomers and 12 known xanthones, were isolated from the stems of Calophyllum membranaceum Gardn. et Champ. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of the enantiomers was determined by using experimental and calculated electronic circular dichroism data. All compounds were screened for their anti-inflammatory effects on LPS-induced BV-2 microglial cells. Among them, six compounds showed remarkable activities with IC50 values of 7.8-36.0 µM.14aANTI-INFLAMMATORY ACTIVITY14aCALOPHYLLUM MEMBRANACEUM GARDN. ET CHAMP.14aCLUSIACEAE14aXANTHONE ENANTIOMERS14aXANTHONES12aYu, M.12aWang, S. J.12aLi, H.12aZhang, G. J.40uhttps://drive.google.com/file/d/1X0JwDO-4mMQRmloY-y_UtwipNCcIuCJq/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d