Wang, C. F.Yang, X. Q. Shi, W. Z. Long, X. Su, S. Cen, R. H. Ding, Z. T. text xx 9999 monographic und

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Metabolism of special endophytes and phytopathogens can be induced by the symbiotic interactions with the host. A phytopathogen Epicoccum sorghinum cultured in host mushroom Thelephora ganbajun medium exhibited different metabolites compared with that of ordinary medium. An unprecedented scaffold possessing the same substructure as perylenequinone mycotoxin, a first methyl rearrangement product of phytotoxin, epoxydon 6-methylsalicylate ester, three undescribed compounds, and an undescribed natural product were isolated from E. sorghinum cultured in T. ganbajun. Episorin A and epicosorin A were produced from E. sorghinum induced by culturing in host medium. Episorin A was the first example of perylenequinone analogue in the natural products. These induced compounds and other metabolites showed notable antibiosis against endogenous fungi, and insect existing in mushroom. Induced episorin A showed significant inhibitory effects on nitric oxide production in LPS-activated macrophages, and anti-acetylcholinesterase with the IC50 at 5.40 ± 0.25 ?M, and 4.32 ?M, respectively, and cytotoxicity against HL-60, A-549, SMMC-7721, MCF-7 and SW480 with IC50 at 14.21 ± 0.53, 17.93 ± 0.22, 18.17 ± 0.63, 28.36 ± 0.43, and 18.20 ± 1.03 ?M. BROAD-SPECTRUM ANTIBIOSIS DIDYMELLACEAE EPICOCCUM SORGHINUM INTERACTION METABOLITE THELEPHORA GANBAJUN THELEPHORACEAE https://drive.google.com/file/d/1HFc0iaBKpni1AIai1nqRnRrT4YE8ZZpU/view?usp=drivesdk https://drive.google.com/file/d/1HFc0iaBKpni1AIai1nqRnRrT4YE8ZZpU/view?usp=drivesdk 250602 20260521091658.0