02279nam a2200313Ia 4500 MX-MdCICY 20260521091658.0 CICY B-19341 The production of broad-spectrum antibiotics from phytopathogen Epicoccum sorghinum by culturing in host edible mushroom Thelephora ganbajun extract PhytoChemistry, 200, p.113221, 2022 Metabolism of special endophytes and phytopathogens can be induced by the symbiotic interactions with the host. A phytopathogen Epicoccum sorghinum cultured in host mushroom Thelephora ganbajun medium exhibited different metabolites compared with that of ordinary medium. An unprecedented scaffold possessing the same substructure as perylenequinone mycotoxin, a first methyl rearrangement product of phytotoxin, epoxydon 6-methylsalicylate ester, three undescribed compounds, and an undescribed natural product were isolated from E. sorghinum cultured in T. ganbajun. Episorin A and epicosorin A were produced from E. sorghinum induced by culturing in host medium. Episorin A was the first example of perylenequinone analogue in the natural products. These induced compounds and other metabolites showed notable antibiosis against endogenous fungi, and insect existing in mushroom. Induced episorin A showed significant inhibitory effects on nitric oxide production in LPS-activated macrophages, and anti-acetylcholinesterase with the IC50 at 5.40 ± 0.25 ?M, and 4.32 ?M, respectively, and cytotoxicity against HL-60, A-549, SMMC-7721, MCF-7 and SW480 with IC50 at 14.21 ± 0.53, 17.93 ± 0.22, 18.17 ± 0.63, 28.36 ± 0.43, and 18.20 ± 1.03 ?M. BROAD-SPECTRUM ANTIBIOSIS DIDYMELLACEAE EPICOCCUM SORGHINUM INTERACTION METABOLITE THELEPHORA GANBAJUN THELEPHORACEAE Wang, C. F.Yang, X. Q. Shi, W. Z. Long, X. Su, S. Cen, R. H. Ding, Z. T. https://drive.google.com/file/d/1HFc0iaBKpni1AIai1nqRnRrT4YE8ZZpU/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 29414 29414 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-19341 2025-06-25 16:24:29 2025-06-25 REF1