01817nam a2200265Ia 4500003001000000005001700010040000900027090001200036245011100048490004000159520087700199650001401076650002701090650001701117650002301134650001401157700001601171700001701187700001601204856015601220942001401376008004101390999001701431952010301448MX-MdCICY20260521091656.0  cCICY  aB-1927310aStructural characterization of three cytotoxic steroidal saponins from the leaves of Agave desmetiana hort0 vPhytoChemistry, 195, p.113057, 20223 aThree steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 - [{O - ? - D - xylopyranosyl (1 ? 2)- ? - L-rhamnopyranosyl (1 ? 3)}-?-D- glucopyranoside), Tigogenin- 3 - ([O- ? -L-rhamnopyranosyl (1 ? 3)- ? - D - glalactopyranosyl (1 ? 2)] - ? - D - glucopyranoside)and Tigogenin- 3 - ([{O - ? - L - rhamnopyranosyl (1 ? 4)} - ? - D - galactopyranosyl (1 ? 3)- ? - D - xylopyranosyl (1 ? 2)] - ? - D - glucopyranoside). Identification and structure elucidation of the isolates were done via 1D and 2D NMR techniques, and chemical methods. Cytotoxic activity for the crude saponins and the three isolated compounds were evaluated against Hepg-2 and Mcf-7 cell lines. Compound 2 proved to be the most cytotoxic against tested cell lines with an IC50 2.97 and 2.49 ?g/ml respectively.14aAGAVACEAE14aAGAVE DESMETIANA HORT.14aCYTOTOXICITY14aSTEROIDAL SAPONINS14aTIGOGENIN12aGabr, N. M.12aGhaly, N. S.12aMina, S. A.40uhttps://drive.google.com/file/d/1q2m1Ixz_XdeR7_WyAuCRINB4iDN0flj3/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx  2LoccREF1250602s9999    xx |||||s2   |||| ||und|d  c29349d29349  00102Loc40708F1aCICYbCICYcREd2025-06-25l0oB-19273r2025-06-25 16:24:28w2025-06-25yREF1