TY  - BOOK
AU  - Gabr,N.M.
AU  - Ghaly,N.S.
AU  - Mina,S.A.
TI  - Structural characterization of three cytotoxic steroidal saponins from the leaves of Agave desmetiana hort
KW  - AGAVACEAE
KW  - AGAVE DESMETIANA HORT
KW  - CYTOTOXICITY
KW  - STEROIDAL SAPONINS
KW  - TIGOGENIN
N2  - Three steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 - [{O - ? - D - xylopyranosyl (1 ? 2)- ? - L-rhamnopyranosyl (1 ? 3)}-?-D- glucopyranoside), Tigogenin- 3 - ([O- ? -L-rhamnopyranosyl (1 ? 3)- ? - D - glalactopyranosyl (1 ? 2)] - ? - D - glucopyranoside)and Tigogenin- 3 - ([{O - ? - L - rhamnopyranosyl (1 ? 4)} - ? - D - galactopyranosyl (1 ? 3)- ? - D - xylopyranosyl (1 ? 2)] - ? - D - glucopyranoside). Identification and structure elucidation of the isolates were done via 1D and 2D NMR techniques, and chemical methods. Cytotoxic activity for the crude saponins and the three isolated compounds were evaluated against Hepg-2 and Mcf-7 cell lines. Compound 2 proved to be the most cytotoxic against tested cell lines with an IC50 2.97 and 2.49 ?g/ml respectively
UR  - https://drive.google.com/file/d/1q2m1Ixz_XdeR7_WyAuCRINB4iDN0flj3/view?usp=drivesdk
ER  -