Ren, X. M. Han, Z. Z. Song, L. X. Lv, Z. Y. Yang, Y. B. Xiao, Y. Zhang, Z. J. text xx 9999 monographic und

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Four new phenolic compounds, 2-{[3-(3,4-dihydroxyphenyl)propanoyl]oxy}propanoic acid (1), 2-{[3-(3,4- dihydroxyphenyl)propanoyl]oxy}propanoic acid methyl (2), (±)3-{2-[1-(3? ,4? -dihydroxy-phenyl)ethyl]-4,5- dihydroxyphenyl}propanoic acid methyl (3), and (±)3-{2-[1-(3? ,4? -dihydroxy-phenyl)ethyl]-4,5-dihydroxyphenyl}propanoic acid (4), together with five known compounds, methyl 3-(3,4-dihydroxyphenyl)-propanoate (5), 3,4-dihydroxybenzenepropionic acid (6), caffeic acid (7), protocatechuic acid (8), and 1,3-trans-5,6-dihydroxy-3-(3? ,4? -dihydroxyphenyl)indan-1-methyl (9)were isolated from the tender leaves of Eucommia ulmoides Oliv. Compound 9 was isolated from Eucommiaceae for the first time. The structures of the new compounds were elucidated from the spectra of 1D NMR and 2D NMR, and MS data. Compounds 1-9 were tested to determine their inhibitory effect on LPS-induced NO production in macrophage RAW264.7 cells. Modest inhibitory activities were observed for compounds 2-5 and 9, with IC50 values ranging from 8.3 to 31.0 ?M. This research enriches the current chemical information regarding the leaves of Eucommia ulmoides Oliv. and provides a reference for further research on its anti-inflammatory effects. TENDER LEAVES OF EUCOMMIA ULMOIDES PHENOLICS ANTI-INFLAMMATORY ACTIVITY https://drive.google.com/file/d/1fNYDce8WsL4GwCS4lKA1CM2xnaqFIeRG/view?usp=drivesdk https://drive.google.com/file/d/1fNYDce8WsL4GwCS4lKA1CM2xnaqFIeRG/view?usp=drivesdk 250602 20260521091655.0