02147nam a2200277Ia 4500 MX-MdCICY 20260521091655.0 CICY B-19246 Four new phenolic compounds from the tender leaves of Eucommia ulmoides Oliv. and their anti-inflammatory activities PhytoChemistry Letters, 44, p.173-177, 2021 Four new phenolic compounds, 2-{[3-(3,4-dihydroxyphenyl)propanoyl]oxy}propanoic acid (1), 2-{[3-(3,4- dihydroxyphenyl)propanoyl]oxy}propanoic acid methyl (2), (±)3-{2-[1-(3? ,4? -dihydroxy-phenyl)ethyl]-4,5- dihydroxyphenyl}propanoic acid methyl (3), and (±)3-{2-[1-(3? ,4? -dihydroxy-phenyl)ethyl]-4,5-dihydroxyphenyl}propanoic acid (4), together with five known compounds, methyl 3-(3,4-dihydroxyphenyl)-propanoate (5), 3,4-dihydroxybenzenepropionic acid (6), caffeic acid (7), protocatechuic acid (8), and 1,3-trans-5,6-dihydroxy-3-(3? ,4? -dihydroxyphenyl)indan-1-methyl (9)were isolated from the tender leaves of Eucommia ulmoides Oliv. Compound 9 was isolated from Eucommiaceae for the first time. The structures of the new compounds were elucidated from the spectra of 1D NMR and 2D NMR, and MS data. Compounds 1-9 were tested to determine their inhibitory effect on LPS-induced NO production in macrophage RAW264.7 cells. Modest inhibitory activities were observed for compounds 2-5 and 9, with IC50 values ranging from 8.3 to 31.0 ?M. This research enriches the current chemical information regarding the leaves of Eucommia ulmoides Oliv. and provides a reference for further research on its anti-inflammatory effects. TENDER LEAVES OF EUCOMMIA ULMOIDES PHENOLICS ANTI-INFLAMMATORY ACTIVITY Ren, X. M. Han, Z. Z. Song, L. X. Lv, Z. Y. Yang, Y. B. Xiao, Y. Zhang, Z. J. https://drive.google.com/file/d/1fNYDce8WsL4GwCS4lKA1CM2xnaqFIeRG/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 29323 29323 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-19246 2025-06-25 16:24:27 2025-06-25 REF1