02498nam a2200277Ia 4500 MX-MdCICY 20260521091632.0 CICY B-18490 Scaffolds from alternating block polyurethanes of poly (?-caprolactone)and poly (ethylene glycol)with stimulation and guidance of nerve growth and better nerve repair than autograft. Journal of biomedical Materials Research Part A, 103(7), p.2355-2364, 2015 Nerve repair scaffolds from novel alternating block polyurethanes (PUCL-alt-PEG)based on PCL and PEG without additional growth factors or proteins were prepared by a particle leaching method. The scaffolds have pore size 10-20 µm and porosity 92percent. Mechanical tests showed that the polyurethane scaffolds have maximum loads of 5.97 ± 0.35 N and maximal stresses of 8.84 ± 0.5 MPa. Histocompatiblity of the nerve repair scaffolds was tested in a SD rat model for peripheral nerve defect treatment. Two types of treatments including PUCL-alt-PEG scaffolds and autografts were compared in rat model. After 32 weeks, bridging of a 12 mm defect gap by the regenerated nerve was observed in all rats. The nerve regeneration was systematically characterized by sciatic function index (SFI), electrophysiology, histological assessment including HE staining, immunohistochemistry, ammonia sliver staining, Masson's trichrome staining and TEM observation. Results revealed that nerve repair scaffolds from PUCL-alt-PEG exhibit better regeneration effects compared to autografts. Electrophysiological recovery was seen in 90percent and 87percent of rats in PUCL-alt-PEG and autograft groups respectively. Biodegradation in vitro and in vivo shows good degradation match of PUCL-alt-PEG scaffolds with nerve regeneration. It demonstrates that plain nerve repair scaffolds from PUCL-alt-PEG biomaterials can achieve peripheral nerve regeneration satisfactorily ALTERNATING BLOCK POLYURETHANES, POLY(E-CAPROLAC-TONE)(PCL) POLY(ETHYLENE GLYCOL)(PEG) SCAFFOLD, PERIPHERY NERVE REPAIR Niu, Y. Li, L. Chen, K. C. Chen, F. Liu, X. Ye, J. Xu, K. https://drive.google.com/file/d/19SuTIupvstmejoV-WjgRfOrtiiPyQ-pq/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 28579 28579 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-18490 2025-06-25 16:24:13 2025-06-25 REF1