Ruan, Q. F. Zhou, X. H. Jiang, S. Q. Yang, B. Jin, J. Cui, H. Zhao, Z. X. text xx 9999 monographic und

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Six previously undescribed cassane diterpenoids, named caesalminaxins O-T (1-6), together with 28 known compounds (7-34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded 1H NMR signal was the first example in cassane diterpenoids. All of the isolates were evaluated for their inhibitory activity against lipopolysaccharide-activated NO production in RAW264.7 cells. Compound 16 showed moderate inhibitory activity with an IC50 value of 17.3??M, which was more potent than the positive control (indomethacin, IC50?=?29.7??M). CAESALPINIA MINAX CASSANE DITERPENOIDS ANTI-INFLAMMATORY ACTIVITY ENOL GROUP https://drive.google.com/file/d/1-MlZYsK0iNStlpIBD6iekWw-vt-uu2RS/view?usp=drivesdk https://drive.google.com/file/d/1-MlZYsK0iNStlpIBD6iekWw-vt-uu2RS/view?usp=drivesdk 250602 20260521091626.0