01725nam a2200289Ia 4500 MX-MdCICY 20260521091626.0 CICY B-18307 Caesalminaxins OT, cassane diterpenoids from the seeds of Caesalpinia minax and their anti-inflammation. Fitoterapia, 134, p.50-57, 2019 Six previously undescribed cassane diterpenoids, named caesalminaxins O-T (1-6), together with 28 known compounds (7-34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded 1H NMR signal was the first example in cassane diterpenoids. All of the isolates were evaluated for their inhibitory activity against lipopolysaccharide-activated NO production in RAW264.7 cells. Compound 16 showed moderate inhibitory activity with an IC50 value of 17.3??M, which was more potent than the positive control (indomethacin, IC50?=?29.7??M). CAESALPINIA MINAX CASSANE DITERPENOIDS ANTI-INFLAMMATORY ACTIVITY ENOL GROUP Ruan, Q. F. Zhou, X. H. Jiang, S. Q. Yang, B. Jin, J. Cui, H. Zhao, Z. X. https://drive.google.com/file/d/1-MlZYsK0iNStlpIBD6iekWw-vt-uu2RS/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 28398 28398 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-18307 2025-06-25 16:02:27 2025-06-25 REF1