01646nam a2200253Ia 4500003001000000005001700010040000900027245010900036490003600145520081900181650002201000650002501022650003101047650001501078700001601093700001601109700001701125700001301142700001201155700001201167700001601179856015601195008004101351MX-MdCICY20260521091626.0  cCICY10aCaesalminaxins OT, cassane diterpenoids from the seeds of Caesalpinia minax and their anti-inflammation.0 vFitoterapia, 134, p.50-57, 20193 aSix previously undescribed cassane diterpenoids, named caesalminaxins O-T (1-6), together with 28 known compounds (7-34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded 1H NMR signal was the first example in cassane diterpenoids. All of the isolates were evaluated for their inhibitory activity against lipopolysaccharide-activated NO production in RAW264.7 cells. Compound 16 showed moderate inhibitory activity with an IC50 value of 17.3??M, which was more potent than the positive control (indomethacin, IC50?=?29.7??M).14aCAESALPINIA MINAX14aCASSANE DITERPENOIDS14aANTI-INFLAMMATORY ACTIVITY14aENOL GROUP12aRuan, Q. F.12aZhou, X. H.12aJiang, S. Q.12aYang, B.12aJin, J.12aCui, H.12aZhao, Z. X.40uhttps://drive.google.com/file/d/1-MlZYsK0iNStlpIBD6iekWw-vt-uu2RS/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d