Liu, J. Dou, X. Chen, C. Chen, C. Liu, C. Xu, M. M. He, C. text xx 9999 monographic und

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N6-methyladenosine (m6A)is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs)in mammalian cells. Disruption of m6A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. RNA REGULATES CHROMATIN TRANSCRIPTION https://drive.google.com/file/d/1BtsNzf7_WsrKTnHVRMOowypaNnI3y_7U/view?usp=drivesdk https://drive.google.com/file/d/1BtsNzf7_WsrKTnHVRMOowypaNnI3y_7U/view?usp=drivesdk 250602 20260521091620.0