Synthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI
Tang, P.
Lin, H. X.
Yuan, T. H.
Cui, Y. M.
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our C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities.
1-DEOXYBACCATIN VI
TAXANE
CYTOTOXICITY
OXIDATION
SYNTHESIS
Natural Product Research, 33(24), p.3478-3484, 2019
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