01868nam a2200361Ia 4500 MX-MdCICY 20260521091616.0 CICY B-17999 Advances in the proteomic investigation of the cell secretome Expert Review of proteomics, 9(3), p.337-345, 2012 Studies of the cell secretome have greatly increased in recent years owing to improvements in proteomic platforms, mass spectrometry instrumentation and to the increased interaction between analytical chemists, biologists and clinicians. Several secretome studies have been implemented in different areas of research, leading to the generation of a valuable secretome catalogs. Secreted proteins continue to be an important source of biomarkers and therapeutic target discovery and are equally valuable in the field of microbiology. Several discoveries have been achieved in vitro using cell culture systems, ex vivo using human tissue specimens and in vivo using animal models. In this review, some of the most recent advances in secretome studies and the fields that have benefited the most from this evolving technology are highlighted. BIOMARKERS CANCER CEREBROSPINAL FLUID EXOSOMES IN VIVO MICRODIALYSIS MASS SPECTROMETRY SECRETOME SERUM SILAC URINE Brown, K. J. Formolo, C. A. Seol, H. Marathi, R. L. Duguez, S. An, E. Hathout, Y. https://drive.google.com/file/d/1LyfQy4TIXPNkf-w3MQe48YOh51wMwhEx/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 28097 28097 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-17999 2025-06-25 16:02:21 2025-06-25 REF1