01606nam a2200229Ia 4500 MX-MdCICY 20260521091550.0 CICY B-17203 The DNA methyltransferase family: a versatile toolkit for epigenetic regulation Nature Reviews Genetics, 19(2), p.81, 2018 The DNA methyltransferase (DNMT)family comprises a conserved set of DNA-modifying enzymes that have a central role in epigenetic gene regulation. Recent studies have shown that the functions of the canonical DNMT enzymes-DNMT1, DNMT3A and DNMT3B-go beyond their traditional roles of establishing and maintaining DNA methylation patterns. This Review analyses how molecular interactions and changes in gene copy numbers modulate the activity of DNMTs in diverse gene regulatory functions, including transcriptional silencing, transcriptional activation and post-transcriptional regulation by DNMT2-dependent tRNA methylation. This mechanistic diversity enables the DNMT family to function as a versatile toolkit for epigenetic regulation. © 2018 Macmillan Publishers Limited, part of Springer Nature. DNA (CYTOSINE 5)METHYLTRANSFERASE 1 DNA METHYLTRANSFERASE DNA METHYLTRANSFERASE 3ª DNA METHYLTRANSFERASE 3 BHISTONE DEACETYLASE 2 Lyko, F. https://drive.google.com/file/d/1QIW4Hufv7rxTtlD_BnWUCxTATTR27hwf/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 27305 27305 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-17203 2025-06-25 16:02:06 2025-06-25 REF1