01527nam a2200193Ia 4500003001000000005001700010040000900027245008400036490004700120520080500167650004000972650002601012650003001038650002801068650002701096700001301123856015601136008004101292MX-MdCICY20260521091550.0  cCICY10aThe DNA methyltransferase family: a versatile toolkit for epigenetic regulation0 vNature Reviews Genetics, 19(2), p.81, 20183 aThe DNA methyltransferase (DNMT)family comprises a conserved set of DNA-modifying enzymes that have a central role in epigenetic gene regulation. Recent studies have shown that the functions of the canonical DNMT enzymes-DNMT1, DNMT3A and DNMT3B-go beyond their traditional roles of establishing and maintaining DNA methylation patterns. This Review analyses how molecular interactions and changes in gene copy numbers modulate the activity of DNMTs in diverse gene regulatory functions, including transcriptional silencing, transcriptional activation and post-transcriptional regulation by DNMT2-dependent tRNA methylation. This mechanistic diversity enables the DNMT family to function as a versatile toolkit for epigenetic regulation. © 2018 Macmillan Publishers Limited, part of Springer Nature.14aDNA (CYTOSINE 5)METHYLTRANSFERASE 114aDNA METHYLTRANSFERASE14aDNA METHYLTRANSFERASE 3ª14aDNA METHYLTRANSFERASE 314aBHISTONE DEACETYLASE 212aLyko, F.40uhttps://drive.google.com/file/d/1QIW4Hufv7rxTtlD_BnWUCxTATTR27hwf/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d