01952nam a2200277Ia 4500 MX-MdCICY 20260521091538.0 CICY B-16817 Redox regulation of plant stem cell fate EMBO Journal, 36(19), p.2844-2855, 2017 Despite the importance of stem cells in plant and animal development, the common mechanisms of stem cell maintenance in both systems have remained elusive. Recently, the importance of hydrogen peroxide (H2O2)signaling in priming stem cell differentiation has been extensively studied in animals. Here, we show that different forms of reactive oxygen species (ROS)have antagonistic roles in plant stem cell regulation, which were established by distinct spatiotemporal patterns of ROS-metabolizing enzymes. The superoxide anion ((Formula presented.)) is markedly enriched in stem cells to activate WUSCHEL and maintain stemness, whereas H2O2 is more abundant in the differentiating peripheral zone to promote stem cell differentiation. Moreover, H2O2 negatively regulates (Formula presented.)biosynthesis in stem cells, and increasing H2O2 levels or scavenging (Formula presented.)leads to the termination of stem cells. Our results provide a mechanistic framework for ROS-mediated control of plant stem cell fate and demonstrate that the balance between (Formula presented.)and H2O2 is key to stem cell maintenance and differentiation. PLANT STEM CELL REACTIVE OXYGEN SPECIES SUPEROXIDE ANION SUPEROXIDE DISMUTASE WUSCHEL Zeng, J. Dong, Z. Wu, H. Tian, Z. Zhao, Z. https://drive.google.com/file/d/1HLGV_YoVkanV8oFbBUi_eY0V4NC0TmJl/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 26921 26921 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-16817 2025-06-25 16:01:58 2025-06-25 REF1