Domurado, D. Fournié, P. Braud, C. Vert, M. Guérin, P. Simonnet, F. text xx 9999 monographic und

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To determine whether degradation could influence the in vivo elimination pattern of poly(ß-malic acid)in mice, radioactive urinary excretion and 14CO2 expiration were studied after intravenous injection of 14C-radiolabeled poly(ß-malic acid)and of its precursor, 14C-malate. The precursor administration led to rapid 14CO2 exhalation, and only negligible urinary elimination. The reverse was observed for the polymer. It was concluded that: (i)the in vivo degradation of poly(ß-malic acid)chains, if any during the 24-h period of the study, did not release detectable malate molecules, (ii)the large urinary excretion of poly(ß-malic acid)was due to the molar masses being less than the renal filtration threshold, (iii)the degradation of the poly(ß-malic acid)chains in blood was slow enough to allow the fraction with higher molar masses to enter the interstitial space of the tissues, and possibly cells. CO2 EXPIRATION BIODEGRADABLE POLYMER IN VIVO FATE PHARMACOKINETICS RADIOACTIVE FOLLOW-UP URINARY EXCRETION https://drive.google.com/file/d/1VwlRwAhqWTkrs4ANwkKpWGWT8qjeSHei/view?usp=drivesdk https://drive.google.com/file/d/1VwlRwAhqWTkrs4ANwkKpWGWT8qjeSHei/view?usp=drivesdk 250602 20260521091508.0