02171nam a2200229Ia 4500003001000000005001700010040000900027245006100036490005500097520140200152650001401554650001901568650002201587650002201609650002801631650003801659700001701697700001301714700001701727856015601744008004101900MX-MdCICY20260521091417.0  cCICY10aTwin-arginine-dependent translocation of folded proteins0 vPhil. Trans. R. Soc., 367(1592), p.1029-1046, 20123 aTwin-arginine translocation (Tat)denotes a protein transport pathway in bacteria, archaea and plant chloroplasts, which is specific for precursor proteins harbouring a characteristic twin-arginine pair in their signal sequences. Many Tat substrates receive cofactors and fold prior to translocation. For a subset of them, proofreading chaperones coordinate maturation and membrane-targeting. Tat translocases comprise two kinds of membrane proteins, a hexahelical TatC-type protein and one or two members of the single-spanning TatA protein family, called TatA and TatB. TatC- and TatAtype proteins form homo- and hetero-oligomeric complexes. The subunits of TatABC translocases are predominantly recovered from two separate complexes, a TatBC complex that might contain some TatA, and a homomeric TatA complex. TatB and TatC coordinately recognize twin-arginine signal peptides and accommodate them in membrane-embedded binding pockets. Advanced binding of the signal sequence to the Tat translocase requires the proton-motive force (PMF)across the membranes and might involve a first recruitment of TatA. When targeted in this manner, folded twin-arginine precursors induce homo-oligomerization of TatB and TatA. Ultimately, this leads to the formation of a transmembrane protein conduit that possibly consists of a pore-like TatA structure. The translocation step again is dependent on the PMF.14aTATA PORE14aTATBC RECEPTOR14aTATA-TYPE PROTEIN14aTATC-TYPE PROTEIN14aPROOFREADING CHAPERONES14aTWIN-ARGININE TRANSLOCATION (TAT)12aFröbel, J.12aRose, P.12aMüller, M.40uhttps://drive.google.com/file/d/10uSL36ryLtmNOqF1h9xtgsIjRd__HfU0/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d