02172nam a2200265Ia 4500 MX-MdCICY 20260521091258.0 CICY B-11866 Preparation and characterization of biodegradable nanoparticles based on amphiphilic poly(3-hydroxybutyrate)-poly(ethylene glycol)- poly(3-hydroxybutyrate)triblock copolymer European Polymer Journal, 42(10), p.2211-2220, 2006 Amphiphilic triblock copolymers of poly(3-hydroxybutyrate)-poly(ethylene glycol)-poly(3-hydroxybutyrate)(PHB- PEG-PHB)were directly synthesized by the ring-opening copolymerization of b-butyrolactone monomer using PEG as macroinitiator. Their structure, thermal properties and crystallization were investigated by 1H NMR, differential scanning calorimetry (DSC)and X-ray diffraction. It was found that both PHB and PEG blocks were miscible. With the increase in the PHB block length, the triblock copolymers became amorphous because amorphous PHB block remarkably depressed the crystallization of the PEG block. Biodegradable nanoparticles with core-shell structure were prepared in aqueous solution from the amphiphilic triblock copolymers, and characterized by 1H NMR, SEM and fluorescence. The hydrophobic PHB segments formed the central solid-like core, and stabilized by the hydrophilic PEG block. The nanoparticle size was close related to the initial concentrations of the nanoparticle dispersions and the compositions of the triblock copolymers. Moreover, the PHB-PEG-PHB nanoparticles also showed good drug loading properties, which suggested that they were very suitable as delivery vehicles for hydrophobic drugs. POLY(3-HYDROXYBUTYRATE) TRIBLOCK COPOLYMER AMPHIPHILIC NANOPARTICLE Chen, Ch. Him Yu, C. Chung Cheng, Y. Yu, P.H.F. Ken Cheung, M. https://drive.google.com/file/d/1KuS1jupMM0A1bXc3m8vBxnbXRMcpclP0/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 22020 22020 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-11866 2025-06-25 14:06:58 2025-06-25 REF1