01796nam a2200301Ia 4500 MX-MdCICY 20260521091238.0 CICY B-11233 Simple and reproducible HPLC-DAD-ESI-MS/MS analysis of alkaloids in Catharanthus roseus roots Journal of Pharmaceutical and Biomedical Analysis, 51(2010), p.65-69, 2009 Catharanthus roseus is one of the most important medicinal plants worldwide. The leaves of this species are the only source of the indolomonoterpenic alkaloids vincristin (leurocristine)and vinblastin (vincaleucoblastine), whose anticancer activity represents powerful therapeutics to many diseases, such as Hodgkin lymphoma. Usually, the remaining plant parts go to waste. Here we describe a phytochemical study on this species roots. Alkaloids in aqueous extracts, the usual form of consumption of this matrix, were studied using HPLC-DAD-ESI-MS/MS, which allowed the identification of 19-S-vindolinine, vindolinine, ajmalicine and an ajmalicine isomer, tabersonine, catharanthine, serpentine and a serpentine isomer. Quantification of the identified compounds revealed that serpentine and its isomer were predominant (64.7 CATHARANTHUS ROSEUS ROOTS HPLC-DAD-ESI-MS/MS ALKALOIDS Ferreres, F. Pereira, D.M. Valentao, P. Oliveira, J.M.A. Faria, J. Gaspar, L. Sottomayor, M. Sottomayor, M. https://drive.google.com/file/d/1AW6z4VqU1HYU6Yvl_6g65UMW3art5iKY/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 21398 21398 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-11233 2025-06-25 14:06:46 2025-06-25 REF1