01802nam a2200205Ia 4500 MX-MdCICY 20260521091214.0 CICY B-10480 Proteomics and regulomics: the yin and yang of functional genomics Mass Spectrometry Reviews, 23(1), p.25-33, 2003 Protein analysis is a field of research with a long history. Recently, the development of a series of proteomics approaches, i.e., simultaneous analyses on all or a majority of proteins in a cell at a given state, has reinvigorated protein analyses. Mass Spectrometry also developed into one of the most versatile technical tools supporting or even enabling many proteomicsoriented approaches, providing a convenient link between experimental protein analysis and the corresponding amino acid sequences. Thus direct links to the genomic sequence can be established, which opens the door for a synergistic combination with genomic sequence analysis. This review focuses especially on aspects of genome-wide transcription control, regulomics in analogy to all the other -omics, and how a combination of MS-based proteomics with in silico regulomics analyses can produce synergistic effects in the quest to understand how cells function. This is illustrated on a real life example showing how the MS-analysis and in silico promoter analysis can extend the list of candidates for signaling pathways, here the MAP kinase pathway PROTEOMICS REGULAMICS FUNCTIONAL GENOMICS Werner, T. https://drive.google.com/file/d/1UIy-N3WgyQDFZOoof5qtTQdgyDENjhlQ/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 20651 20651 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-10480 2025-06-25 14:06:32 2025-06-25 REF1