02462nam a2200265Ia 4500003001000000005001700010040000900027245012800036490004400164520157300208650001701781650001501798650002101813650001901834650002301853650001601876700001901892700001901911700001601930700001701946700001601963700002001979856015601999008004102155MX-MdCICY20260521091154.0  cCICY10aSynthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates0 vBioMaterials, 29(12), p.1762-1775, 20083 aBone defects, such as compressive fractures in the vertebral bodies, are frequently treated with acrylic bone cements (e.g., PMMA). Although these biomaterials have sufficient mechanical properties for fixing the fracture, they are non-degradable and do not remodel or integrate with host tissue. In an alternative approach, biodegradable polyurethane (PUR)networks have been synthesized that are designed to integrate with host tissue and degrade to non-cytotoxic decomposition products. PUR networks have been prepared by two-component reactive liquid molding of low-viscosity quasi-prepolymers derived from lysine polyisocyanates and poly(3-caprolactone-co-DL-lactide-co-glycolide)triols. The composition, thermal transitions, and mechanical properties of the biomaterials were measured. The values of Young's modulus ranged from 1.20e 1.43 GPa, and the compressive yield strength varied from 82 to 111 MPa, which is comparable to the strength of PMMA bone cements. In vitro, the materials underwent controlled biodegradation to non-cytotoxic decomposition products, and supported the attachment and proliferation of MC3T3 cells. When cultured in osteogenic medium on the PUR networks, MC3T3 cells deposited mineralized extracellular matrix, as evidenced by von Kossa staining and tetracycline labeling. Considering the favorable mechanical and biological properties, as well as the low-viscosity of the reactive intermediates used to prepare the PUR networks, these biomaterials are potentially useful as injectable, biodegradable bone ements for fracture healing.14aPOLYURETHANE14aINJECTABLE14aBIOCOMPATIBILITY14aBIODEGRADATION14aCELL PROLIFERATION14aCOMPRESSION12aGuelcher, S.A.12aSrinivasan, A.12aDumas, J.E.12aDidier, J.E.12aMcbride, S.12aHollinger, J.E.40uhttps://drive.google.com/file/d/145clYlIS1vFH0EouJOIMASlsr1SAoBL9/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d