01858nam a2200313Ia 4500003001000000005001700010040000900027090001100036245008900047490003900136520089200175650001801067650000801085650000801093700001101101700001301112700001501125700001101140700001101151700001401162700001301176700001301189700001201202856015601214942001401370008004101384999001701425952010201442MX-MdCICY20260521091143.0  cCICY  aB-948310aAntioxidant activity of gallic acid from rose flowers in senescence accelerated mice0 vLife Sciences, 77, p.230-240, 20053 aThe activities of the antioxidant enzymes catalase (CAT)and glutathione peroxidase (GPx)in the blood and liver of the aging model induced by injection of different doses of D-gal into normal mice, and in senescence accelerated mice (SAM)of different ages, were determined. The results showed that the enzyme activities in the Dgal treated mice did not alter appreciably but the enzyme activities in blood of the SAM declined significantly with the increase in age, especially in the 9-month-old SAM. When gallic acid purified from rose flowers was used to treat the 9-month-old male SAM, it not only reinstated the activities of CAT and GPx but also significantly reduced the amount of malondialdehyde (MDA)in the liver, brain and kidney. The results demonstrated that 9-month-old male SAM represent an appropriate animal model to evaluate the antioxidant activities of natural products.14aANIMAL MODELS14aCAT14aGPX12aLi, L.12aNg, T.B.12aGao, T, W.12aLi, W.12aFu, M.12aNiu, S.M.12aZhao, L.12aZhao, L.12aLiu, F.40uhttps://drive.google.com/file/d/1oXpKaxUR09A01O1SeF_jLjFoEscDviNq/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx  2LoccREF1250602s9999    xx |||||s2   |||| ||und|d  c19672d19672  00102Loc40708F1aCICYbCICYcREd2025-06-25l0oB-9483r2025-06-25 14:06:13w2025-06-25yREF1