01664nam a2200265Ia 4500003001000000005001700010040000900027245006100036490004800097520085600145650001701001650001201018650001001030650002401040650002001064650001601084700001801100700002001118700001601138700001601154700001201170700001901182856015601201008004101357MX-MdCICY20260521091133.0  cCICY10aPlant cell factories as a source for anti-cancer lignans0 vPhytoChemistry Reviews, 1(1), p.27-35, 20023 aThe review places podophyllotoxin, a powerful anti-cancer material used in clinical treatment of small cell cancers, in focus. The economical synthesis of podophyllotoxin is not feasible and demand for this material outstrips supply. At present, Podophyllum hexandrum (Indian May apple)is the commercial source but it grows in an inhospitable region (the Himalayas)where it is collected from wild stands. Furthermore, the plant is now an endangered species. Alternative sources of podophyllotoxin are considered, e.g., the supply of podophyllotoxin and related lignans by establishing plant cell cultures that can be grown in fermentation vessels. Increase of product yields, by variation of medium and culture conditions or by varying the channelling of precursors into side-branches of the biosynthetic pathway by molecular approaches, are discussed14aBIOSYNTHESIS14aLIGNANS14aLINUM14aPLANT CELL CULTURES14aPODOPHYLLOTOXIN14aPODOPHYLLUM12aArroo, R.R.J.12aAlfermann, A.W.12aMedarde, M.12aPetersen, M12aPras, N12aWoolley, J. G.40uhttps://drive.google.com/file/d/1Sgvlw1S6ELoKv0QrYhrPPQ4qTkXrOLwN/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx250602s9999    xx |||||s2   |||| ||und|d