01907nam a2200253Ia 4500 MX-MdCICY 20260521091058.0 CICY B-7989 Viroids: an Ariadne's thread into the RNA labyrinth EMBO Reports, 7(6), p.593-598, 2006 Viroids are structurally, functionally and evolutionarily different from viruses. Despite their small, non-protein-encoding, singlestranded circular RNA genome, viroids can infect higher plants and cause certain diseases. Members of the two viroid families, Pospiviroidae and Avsunviroidae, have evolved to usurp the transcriptional machinery of their host nuclei and chloroplasts, respectively, in which replication proceeds through a rolling-circle mechanism involving RNA polymerization, cleavage and ligation. Remarkably, viroids subvert certain DNA-dependent RNA polymerases to transcribe RNA templates, and, in the family Avsunviroidae, post-transcriptional cleavage is catalysed by hammerhead ribozymes. Viroids are models for studying RNA evolution and for analysing RNA transport in plants, because they can move intracellularly, intercellularly through plasmodesmata and to distal parts of the plant through the vascular system. Viroids elicit RNA-silencing phenomena, which might mediate some of their biological properties, including pathogenesis. As some viroids behave as catalytic RNAs, they are regarded as remnants of the RNA world. GENE SILENCING RIBOZYMES RNA TRANSPORT RNA WORLD VIROIDS Daròs, J.A. Santiago, F.E. Flores, R. https://drive.google.com/file/d/1-enw7IO84nT-O18-3K4EWqCJBUclxOaj/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 18240 18240 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-7989 2025-06-25 12:47:11 2025-06-25 REF1