02103nam a2200289Ia 4500003001000000005001700010040000900027090001100036245011200047490005700159520109700216650001601313650003101329650003101360650001801391650000901409700001301418700001301431700001301444700001401457700001201471856015601483942001401639008004101653999001701694952010201711MX-MdCICY20260521090843.0  cCICY  aB-365710aTrichostatin A and vorinostat promote adipogenic differentiation through H3K9 acetylation and dimethylation0 vResearch in veterinary Science, 126, p.207-212, 20193 aTo explore the effect of epigenetic modification on the differentiation of goat adipose-derived stem cells in vitro, we used two common epigenetic modification inhibitors, trichostatin A and vorinostat, to treat cashmere goat adipose-derived stem cells and induce adipocyte differentiation. The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG)transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. We conclude that adipocyte differentiation is regulated dynamically by different histone modifications. The areas of acetylation and demethylation changed by trichostatin A and vorinostat are the basis for further research on the mechanism of PPARG promoter to regulate adipocytes differentiation and provide research theroies for using adipose-derived stem cells as donor to produce transgenic animals to improve meat quality improvement.14aACETYLATION14aADIPOGENIC DIFFERENTIATION14aADIPOSE-DERIVED STEM CELLS14aDIMETHYLATION14aGOAT12aWang, X.12aWang, Z.12aWang, Q.12aLiang, H.12aLiu, D.40uhttps://drive.google.com/file/d/1S-lPYqOR5vk2dkl2Ba4VZ1RR3w1u5pH2/view?usp=drivesdkzPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx  2LoccREF1250602s9999    xx |||||s2   |||| ||und|d  c13975d13975  00102Loc40708F1aCICYbCICYcREd2025-06-25l0oB-3657r2025-06-25 12:24:27w2025-06-25yREF1