01989nam a2200277Ia 4500 MX-MdCICY 20260521090843.0 CICY B-3657 Trichostatin A and vorinostat promote adipogenic differentiation through H3K9 acetylation and dimethylation Research in veterinary Science, 126, p.207-212, 2019 To explore the effect of epigenetic modification on the differentiation of goat adipose-derived stem cells in vitro, we used two common epigenetic modification inhibitors, trichostatin A and vorinostat, to treat cashmere goat adipose-derived stem cells and induce adipocyte differentiation. The results showed that trichostatin A and vorinostat changed the relative amounts of H3K9 acetylation and dimethylation in the upstream sequence of PPARG, increased peroxisome proliferator-activated receptor gamma (PPARG)transcription before differentiation and then promoted adipocyte differentiation, and regulated the expression of adipocyte-specific genes. We conclude that adipocyte differentiation is regulated dynamically by different histone modifications. The areas of acetylation and demethylation changed by trichostatin A and vorinostat are the basis for further research on the mechanism of PPARG promoter to regulate adipocytes differentiation and provide research theroies for using adipose-derived stem cells as donor to produce transgenic animals to improve meat quality improvement. ACETYLATION ADIPOGENIC DIFFERENTIATION ADIPOSE-DERIVED STEM CELLS DIMETHYLATION GOAT Wang, X. Wang, Z. Wang, Q. Liang, H. Liu, D. https://drive.google.com/file/d/1S-lPYqOR5vk2dkl2Ba4VZ1RR3w1u5pH2/view?usp=drivesdk Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx Loc REF1 250602s9999 xx |||||s2 |||| ||und|d 13975 13975 0 0 Loc 0 0 F1 CICY CICY RE 2025-06-25 0 B-3657 2025-06-25 12:24:27 2025-06-25 REF1