Geranylgeraniol is a potent inducer of apoptosis in tumor cells
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TextSeries: ; The Journal of BioChemistry, 117(1), p.11-13, 1995Contained works: - Ohizumi, H
- Masuda, Y
- Nakajo, S
- Sakai, I
- Ohsawa, S
- Nakaya, K
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We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.
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