Caesalminaxins OT, cassane diterpenoids from the seeds of Caesalpinia minax and their anti-inflammation.
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TextSeries: ; Fitoterapia, 134, p.50-57, 2019Contained works: - Ruan, Q. F
- Zhou, X. H
- Jiang, S. Q
- Yang, B
- Jin, J
- Cui, H
- Zhao, Z. X
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Six previously undescribed cassane diterpenoids, named caesalminaxins O-T (1-6), together with 28 known compounds (7-34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded 1H NMR signal was the first example in cassane diterpenoids. All of the isolates were evaluated for their inhibitory activity against lipopolysaccharide-activated NO production in RAW264.7 cells. Compound 16 showed moderate inhibitory activity with an IC50 value of 17.3??M, which was more potent than the positive control (indomethacin, IC50?=?29.7??M).
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