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N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.

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TextSeries: ; Science, 367(6477), p.580-586, 2020Contained works:

Liu, J
Dou, X
Chen, C
Chen, C
Liu, C
Xu, M. M
He, C

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Abstract: N6-methyladenosine (m6A)is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs)in mammalian cells. Disruption of m6A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription.

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N6-methyladenosine (m6A)is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs)in mammalian cells. Disruption of m6A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription.

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