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Optimization of Fabrication Parameters To Produce Chitosan-Tripolyphosphate Nanoparticles for Delivery of Tea Catechins

Material type: TextSeries: ; J. Agric. Food Chem., 56(16), p.7451-7458, 2008Contained works:
  • Hu, B
  • Pan, C
  • Sun, Y
  • Hou, Z
  • Ye, H
  • Hu, B
  • Zeng, X
Subject(s): Online resources: Abstract: This work investigated the polyanion-initiated gelation process in fabricating chitosan-tripolyphosphate (CS-TPP)nanoparticles intended to be used as carriers for delivering tea catechins. The results demonstrated that the particle size and surface charge of CS-TPP nanoparticles could be controlled by fabrication conditions. For preparation of CS-TPP nanoparticles loaded with tea catechins, the effects of modulating conditions including contact time between CS and tea catechins, CS molecular mass, CS concentration, CS-TPP mass ratio, initial pH value of CS solution, and concentration of tea catechins on encapsulation efficiency and the release profile of tea catechins in vitro were examined systematically. The study found that the encapsulation efficiency of tea catechins in CSTPP nanoparticles ranged from 24 to 53
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This work investigated the polyanion-initiated gelation process in fabricating chitosan-tripolyphosphate (CS-TPP)nanoparticles intended to be used as carriers for delivering tea catechins. The results demonstrated that the particle size and surface charge of CS-TPP nanoparticles could be controlled by fabrication conditions. For preparation of CS-TPP nanoparticles loaded with tea catechins, the effects of modulating conditions including contact time between CS and tea catechins, CS molecular mass, CS concentration, CS-TPP mass ratio, initial pH value of CS solution, and concentration of tea catechins on encapsulation efficiency and the release profile of tea catechins in vitro were examined systematically. The study found that the encapsulation efficiency of tea catechins in CSTPP nanoparticles ranged from 24 to 53

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