Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions (Record no. 28633)
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| campo de control de longitud fija | 03650nam a2200241Ia 4500 |
| 003 - IDENTIFICADOR DE NÚMERO DE CONTROL | |
| campo de control | MX-MdCICY |
| 005 - FECHA Y HORA DE LA ÚLTIMA TRANSACCIÓN | |
| campo de control | 20260521091633.0 |
| 040 ## - FUENTE DE CATALOGACIÓN | |
| Centro/agencia transcriptor | CICY |
| 090 ## - LOCALMENTE ASIGNADO TIPO-LC NÚMERO DE CLASIFICACIÓN (OCLC); NÚMERO DE CLASIFICACIÓN LOCAL (RLIN) | |
| Número de clasificación (OCLC) (R) ; Numero de clasificación, CALL (RLIN) (NR) | B-18544 |
| 008 - DATOS DE LONGITUD FIJA--INFORMACIÓN GENERAL | |
| campo de control de longitud fija | 250602s9999 xx |||||s2 |||| ||und|d |
| 245 10 - MENCIÓN DEL TÍTULO | |
| Título | Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions |
| 490 0# - MENCIÓN DE SERIE | |
| Designación de volumen o secuencia | Biomedical Materials, 3(3), p.034108, 2008 |
| 520 3# - RESUMEN, ETC. | |
| Sumario, etc. | The increasing use of biodegradable devices in tissue engineering and regenerative medicine means it is essential to study and understand their degradation behaviour. Accelerated degradation systems aim to achieve similar degradation profiles within a shorter period of time, compared with standard conditions. However, these conditions only partially mimic the actual situation, and subsequent analyses and derived mechanisms must be treated with caution and should always be supported by actual long-term degradation data obtained under physiological conditions. Our studies revealed that polycaprolactone (PCL)and PCL-composite scaffolds degrade very differently under these different degradation conditions, whilst still undergoing hydrolysis. Molecular weight and mass loss results differ due to the different degradation pathways followed (surface degradation pathway for accelerated conditions and bulk degradation pathway for simulated physiological conditions). Crystallinity studies revealed similar patterns of recrystallization dynamics, and mechanical data indicated that the scaffolds retained their functional stability, in both instances, over the course of degradation. Ultimately, polymer degradation was shown to be chiefly governed by molecular weight, crystallinity susceptibility to hydrolysis and device architecture considerations whilst maintaining its thermodynamic equilibrium.The increasing use of biodegradable devices in tissue engineering and regenerative medicine means it is essential to study and understand their degradation behaviour. Accelerated degradation systems aim to achieve similar degradation profiles within a shorter period of time, compared with standard conditions. However, these conditions only partially mimic the actual situation, and subsequent analyses and derived mechanisms must be treated with caution and should always be supported by actual long-term degradation data obtained under physiological conditions. Our studies revealed that polycaprolactone (PCL)and PCL-composite scaffolds degrade very differently under these different degradation conditions, whilst still undergoing hydrolysis. Molecular weight and mass loss results differ due to the different degradation pathways followed (surface degradation pathway for accelerated conditions and bulk degradation pathway for simulated physiological conditions). Crystallinity studies revealed similar patterns of recrystallization dynamics, and mechanical data indicated that the scaffolds retained their functional stability, in both instances, over the course of degradation. Ultimately, polymer degradation was shown to be chiefly governed by molecular weight, crystallinity susceptibility to hydrolysis and device architecture considerations whilst maintaining its thermodynamic equilibrium. |
| 650 14 - PUNTO DE ACCESO ADICIONAL DE MATERIA--TÉRMINO DE MATERIA | |
| Término de materia o nombre geográfico como elemento de entrada | DYNAMICS |
| 650 14 - PUNTO DE ACCESO ADICIONAL DE MATERIA--TÉRMINO DE MATERIA | |
| Término de materia o nombre geográfico como elemento de entrada | POLYMER DEGRADATION |
| 650 14 - PUNTO DE ACCESO ADICIONAL DE MATERIA--TÉRMINO DE MATERIA | |
| Término de materia o nombre geográfico como elemento de entrada | POLYCAPROLACTONE-BASED |
| 700 12 - ENTRADA AGREGADA--NOMBRE PERSONAL | |
| Nombre de persona | Lam, C. X. |
| 700 12 - ENTRADA AGREGADA--NOMBRE PERSONAL | |
| Nombre de persona | Savalani, M. M. |
| 700 12 - ENTRADA AGREGADA--NOMBRE PERSONAL | |
| Nombre de persona | Teoh, S. H. |
| 700 12 - ENTRADA AGREGADA--NOMBRE PERSONAL | |
| Nombre de persona | Hutmacher, D. W. |
| 856 40 - LOCALIZACIÓN Y ACCESO ELECTRÓNICOS | |
| Identificador Uniforme de Recurso | <a href="https://drive.google.com/file/d/1LKNFJxH0mwNOtJZq8A25wfDSkWyDNCP5/view?usp=drivesdk">https://drive.google.com/file/d/1LKNFJxH0mwNOtJZq8A25wfDSkWyDNCP5/view?usp=drivesdk</a> |
| Nota pública | Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 ## - ELEMENTOS DE ENTRADA SECUNDARIOS (KOHA) | |
| Fuente de la clasificación o esquema de estantería | |
| Tipo de ítem Koha | REF1 |
| Estatus retirado | Estado de pérdida | Fuente de la clasificación o esquema de estantería | Estado de daño | No para préstamo | Colección | Biblioteca de origen | Biblioteca actual | Ubicación en estantería | Fecha de adquisición | Total de préstamos | Signatura topográfica completa | Visto por última vez | Precio de reemplazo | Tipo de ítem Koha |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CICY | CICY | 25/06/2025 | B-18544 | 25/06/2025 | 25/06/2025 | REF1 |