Salinity stress is one of the major abiotic constraints that limit plant growth and yield, which thereby is a serious concern to world food security. It adversely affects crop production by inducing hyperosmotic stress and ionic toxicity as well as secondary stresses such as oxidative stress, all of which disturb optimum physiology and metabolism. Nonetheless, various strategies have been employed to improve salt tolerance in crop plants, among which the application of Melatonin (Mel)could also be used as it has demonstrated promising results. The ongoing experimental evidence revealed that Mel is a pleiotropic signaling molecule, which besides being involved in various growth and developmental processes also mediates environmental stress responses. The current review systematically discusses and summarizes how Mel mediates the response of plants under salt stress and could optimize the balance between plant growth performances and stress responses. Specifically, it covers the latest advances of Mel in fine-tuning the signaling in plants. Furthermore, it highlights plant-built tolerance of salt stress by manifesting the biosynthesis of Mel, its cross talks with nitric oxide (NO), and Mel as a multifaceted antioxidant molecule.